Author(s): Shahid Yousuf
Gall bladder is the small sac-shaped organ beneath the liver, in which bile is stored after secretion by the liver and before releasing into the intestine. Gallbladder cancer involving the gastrointestinal tract is the fifth most common cancer occurring worldwide, but it is the most common malignant tumour of the biliary tract worldwide. Gallbladder cancer is now considered a distinct clinical entity, allowing for a separate analysis from that of other malignancies of the biliary tree. The marked improvement in the outcome of patients with gallbladder cancer in the last decade is because of the aggressive radical surgical approach that has been adopted, and improvements in surgical techniques and peri-operative care. To understand the mechanism and treatment of gall bladder cancer international collaboration is needed to enhance our knowledge. The present review encompasses the involvement of genetic mechanism of gallbladder cancer and focuses the elucidation of molecular mechanisms of gallbladder cancer. An effort towards the consolidation of these is made here.
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